I was looking over a signature sheet from the consumer group I started and ran for three years in the early 90s. All of the issues that we worked on then are still in play. Just for the record, those issues included health insurance reform, NAFTA, the Clean Water Act and campaign finance laws. We really haven't succeeded in changing anything on those fronts. Looks like Nader had a point about both parties selling out to corporate interests.
Right now, if I had to pick two issues to really work on I would pick social security and net neutrality. I would probably like my president to show a little bit more backbone as well and negotiate like he's not trying to lose the entirety of the Great Society/New Deal programs that make living in the United States bearable.